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Stop using tramadol and call your doctor at once if you have any of these serious side effects: opana agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting; seizure (convulsions); a red, blistering, peeling skin rash; or .
Specifically, tramadol both opana inhibits serotonin and norepinephrine reuptake AND activates opiate receptors in the central nervous system to enhancing the inhibitory effects on pain transmission in the spinal cord . Tramadol works by changing the way the brain and body perceive opana pain .

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